Contents.1 Description/What is RAxML?RAxML-HPC (randomized axelerated maximum likelihood for high performance computing)is a sequential and parallel program for inference of large phylogenies with maximumlikelihood (ML). Low-level technical optimizations, a modification of the search algorithm,and the use of the GTR+CAT approximation as replacement for GTR+Γ yield a programthat is between 2.7 and 52 times faster than the previous version of RAxML.A large-scale performance comparison with GARLI, PHYML, IQPNNI and MrBayes on realdata containing 1000 up to 6722 taxa shows that RAxML requires at least 5.6 times lessmain memory and yields better trees in similar times than the best competing program(GARLI) on datasets up to 2500 taxa. On datasets ≥4000 taxa it also runs 2–3 timesfaster than GARLI.RAxML has been parallelized with MPI to conduct parallel multiple bootstrapsand inferences on distinct starting trees.
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January 2023
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